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Computation-aided Microscopic Imaging Ellipsometry for Biosensing - Yia-Chung Chang - Mardi 17 juin 2014 à 11 h

Yia-Chung Chang - Académie Sinica de Taiwan

Mardi 17 juin 2014 à 11 h - INSP - 4 place Jussieu - 75252 PARIS Cedex 05 - Barre 22-32 - 2e étage, salle 201


The development of functionalized nanostructures has recently attracted a great deal of research interests. Among a variety of nanostructures, a myriad of studies related to noble metal nanoparticles have been conducted in hope of utilizing their strong interaction with light for physical, chemical, and biological applications. Here we discuss the use of microscopic imaging ellipsometry measurements combined with efficient theoretical modeling to reveal the size, shape, and distribution of clusters of gold nanoparticles and semiconductor microspheres on a substrate in air or liquid. These obtained distribution properties are in good agreement with scanning electron microscopy (SEM) measurements. We have also studied the ellipsometric response of various protein molecules attached to gold nanoparticles (which support plasmonic resonances) or semiconductor microspheres (which support whispering-gallery mode resonances) on a substrate. We monitor the induced changes in polarization state or phase of reflected light from the surface the sample and we use these changes versus the photon energy as a sensing signal to detect the interaction of biomolecules with the prepared surface.

References :

1. Optical metrology of randomly-distributed Au colloids on a multilayer film, S.-H. Hsu, Y.-C. Chang*, Y.-C. Chen, P.-K. Wei, Y. D. Kim, Optics Exp. 18, 1310-15 (2010).
2. Surface plasmon resonance ellipsometry based sensor for studying biomolecular interaction, R. S. Moirangthem, Y. C. Chang*, S. H. Hsu, P. K. Wei, Biosensors and Bioelectronics 25, 2633-38 (2010).
3. Ellipsometry study on gold-nanoparticle-coated gold thin film for biosensing application, R. S. Moirangthema, Y.-C. Chang*, P.-K. Wei, Bio. Opt. Exp. 2, 2569 (2011)
4. Enhanced localized plasmonic detections using partially-embedded gold nanoparticles and ellipsometric measurements, R. S. Moirangthem, M. T. Yaseen, P.-K. Wei, J. Y. Cheng, and Y. C. Chang*, Bio Opt. Exp. 3, 899 (2012).
5. Effect of clustering on ellipsometric spectra of randomly distributed gold nanoparticles on a substrate, H-Y Xie, Y-C Chang*, G. Li, S-H Hsu, Optics Exp., 21, 3091–3102 (2013)
6. Optical cavity modes of a single crystalline zinc oxide microsphere, R. S. Moirangthem, P-J Cheng, P. C-H Chien, T. H. Ngo, S-W Chang, C-H Tien, and Y-C Chang*, Optics Exp., 21, 3010–3020 (2013)