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Nanophotonics for application in biosensing

Yia-Chung Chang

The development of functionalized nanostructures has recently attracted a great deal of research interests. Among a variety of nanostructures, a myriad of studies related to noble metal nanoparticles have been conducted in hope of utilizing their strong interaction with light for physical, chemical, and biological applications. Here we discus the sue of spectroscopic ellipsometry (SE) measurements combined with efficient theoretical modeling to reveal the size, shape, and distribution of randomly-distributed gold nanoparticles on a glass substrate. These obtained distribution properties are in good agreement with scanning electron microscopy (SEM) measurements. We have also studied the ellipsometric response of various protein molecules attached to gold nanoparticles (AuNPs) on a substrate. We monitor the induced changes in polarization state or phase of reflected light from the surface which depend on surface properties of the sample and we use these changes versus the photon energy as a sensor signal to detect the interaction of biomolecules with the prepared surface.

References :

1.Optical metrology of randomly-distributed Au colloids on a multilayer film, S.-H. Hsu, Y.-C. Chang*, Y.-C. Chen, P.-K. Wei, Y. D. Kim, Optics Exp. 18, 1310-15 (2010).

2. Surface plasmon resonance ellipsometry based sensor for studying biomolecular interaction, R. S. Moirangthem, Y. C. Chang*, S. H. Hsu, P. K. Wei, Biosensors and Bioelectronics 25, 2633-38 (2010).

3.Ellipsometry study on gold-nanoparticle-coated gold thin film for biosensing application, R. S. Moirangthema, Y.-C. Chang*, P.-K. Wei, Bio. Opt. Exp. 2, 2569 (2011)
Enhanced localized plasmonic detections using partially-embedded gold nanoparticles and ellipsometric measurements, R. S. Moirangthem, M. T. Yaseen, P.-K. Wei, J. Y. Cheng, and Y. C. Chang*, Bio Opt. Exp. 3, 899 (2012).